Important Safety Information and Indication
  • BeneFix is contraindicated in patients who have manifested life-threatening, immediate hypersensitivity reactions, including anaphylaxis, to the product or its components, including hamster protein.
  • Hypersensitivity reactions, including anaphylaxis, have been reported with BeneFix. Closely monitor patients for signs and symptoms of acute anaphylaxis, particularly during the early phases of initial exposure to the product. Immediately discontinue the administration of the product and initiate appropriate treatment if symptoms occur.
  • Patients may develop hypersensitivity to hamster (CHO) protein as BeneFix contains trace amounts.
  • BeneFix has been associated with the development of thromboembolic complications, including patients receiving continuous infusion through a central venous catheter. The safety and efficacy of BeneFix administration by continuous infusion have not been established.
  • Neutralizing antibodies (inhibitors) have been reported following the administration of BeneFix. If expected plasma factor IX activity levels are not attained, or if the patient presents with an allergic reaction, or if bleeding is not controlled following an expected dose of BeneFix, perform an assay that measures factor IX inhibitor concentration.
  • The most common adverse reactions (>5%) from clinical trials were nausea, injection site reaction, injection site pain, headache, dizziness and rash.

Indication

BeneFix, Coagulation Factor IX (Recombinant), is a human blood coagulation factor indicated in adult and pediatric patients with hemophilia B (congenital factor IX deficiency or Christmas disease) for the control and prevention of bleeding episodes and peri-operative management.

Limitations of use:

BeneFix is NOT indicated for:

  • treatment of other factor deficiencies (eg, factors II, VII, VIII and X),
  • treatment of hemophilia A patients with inhibitors to factor VIII,
  • reversal of coumarin-induced anticoagulation,
  • treatment of bleeding due to low levels of liver-dependent coagulation factors.

Please see Full Prescribing Information for BeneFix.

Reference

  • 1. Center for Biologics Evaluation and Research, US Food and Drug Administration, US Department of Health and Human Services. CBER Approval Letter, Coagulation Factor IX (Recombinant), Genetics Institute, Inc. http://www.fda.gov/BiologicsBloodVaccines/BloodBloodProducts/ApprovedProducts/LicensedProductsBLAs/FractionatedPlasmaProducts/
    ucm057039.htm. Published February 11, 1997. Accessed November 14, 2016.

Reference

  • 1. Center for Biologics Evaluation and Research, US Food and Drug Administration, US Department of Health and Human Services. CBER Approval Letter, Coagulation Factor IX (Recombinant), Genetics Institute, Inc. http://www.fda.gov/BiologicsBloodVaccines/BloodBloodProducts/ApprovedProducts/LicensedProductsBLAs/FractionatedPlasmaProducts/
    ucm057039.htm. Published February 11, 1997. Accessed November 14, 2016.

Reference

  • 1. Center for Biologics Evaluation and Research, US Food and Drug Administration, US Department of Health and Human Services. CBER Approval Letter, Coagulation Factor IX (Recombinant), Genetics Institute, Inc. http://www.fda.gov/BiologicsBloodVaccines/BloodBloodProducts/ApprovedProducts/LicensedProductsBLAs/FractionatedPlasmaProducts/
    ucm057039.htm. Published February 11, 1997. Accessed November 14, 2016.

Reference

  • 1. Center for Biologics Evaluation and Research, US Food and Drug Administration, US Department of Health and Human Services. CBER Approval Letter, Coagulation Factor IX (Recombinant), Genetics Institute, Inc. http://www.fda.gov/BiologicsBloodVaccines/BloodBloodProducts/ApprovedProducts/LicensedProductsBLAs/FractionatedPlasmaProducts/
    ucm057039.htm. Published February 11, 1997. Accessed November 14, 2016.

Financial Support

Pfizer Hemophilia Connect—A one-stop destination to access all of our resources for eligible patients

  • One number with access to all of Pfizer Hemophilia's resources and support programs
  • Financial support programs for eligible patients
  • Insurance counseling, prior authorization assistance, and appeals support for insured patients
  • Centralized service for patients, caregivers, and hemophilia treatment centers
  • Learn about community resources like Patient Affairs Liaisons
Pfizer Hemophilia Connect

Call Pfizer Hemophilia Connect at 1.844.989.HEMO(4366)

Pfizer Factor Savings Card—Your eligible patients may save up to $12,000 per year on BeneFix

Factor Savings Card is support for current factor patients. Eligible patients may save up to $12,000 annually in 3 simple steps. This savings card may be used to help cover co-pay, deductible, and coinsurance costs associated with Pfizer factor products.

Getting started: Enroll online:

1. Fill out the registration form by clicking the image to the right

If your patient is eligible, he or she will get access to an online registration form to fill in his or her information.

2. Download the card

Once the registration has been completed, the Factor Savings Card can be downloaded and printed out.

3. Keep the card and use it

Your patient may use the card when filling his or her prescription for every purchase until the maximum benefit of $12,000 has been reached.

Factor Savings Card

Click image to download card.

To request cards, please contact your representative, call 1-844-989-HEMO(4366),
or get it now.

Terms and Conditions apply.

This card will be accepted only at participating factor providers. This coupon is not health insurance.

If you have any questions about the use of the Pfizer Factor Savings Card, please call 1.844.989.HEMO(4366) or send questions to: Pfizer Factor Savings Program, 2250 Perimeter Park Drive, Suite 300, Morrisville, NC 27560. The Pfizer Factor Savings Card cannot be combined with other offers and is limited to one per person.


Download a compressive guide on financial support from Pfizer Hemophilia.

OFFER TERMS: By using the Pfizer Factor Savings Card, you acknowledge that you currently meet the eligibility criteria and will comply with the terms and conditions described below:

The Card is not valid for prescriptions that are eligible to be reimbursed, in whole or in part, by Medicaid, Medicare, Tricare, or other federal or state health care programs (including any state prescription drug assistance programs) and the Government Health Insurance Plan available in Puerto Rico (formerly known as “La Reforma de Salud”). You may receive a total benefit of $12,000 per calendar year, or the amount of your co-pay over one year, whichever is less. This Card is not valid when the entire cost of your prescription drug is eligible to be reimbursed by your private insurance plans or other health or pharmacy benefit programs. You must deduct the value of this offer from any reimbursement request submitted to your insurance plan, either directly by you or on your behalf. The Card is not valid where prohibited by law. The Card cannot be combined with any other rebate/coupon, free trial, or similar offer for the specified prescription. The Card will be accepted only at participating factor suppliers. This Card is not health insurance. Offer good only in the United States and Puerto Rico. The Card is limited to 1 per person during this offering period and is not transferable. Pfizer reserves the right to rescind, revoke, or amend this offer without notice. Offer expires 12/31/18. No membership fees. Go to PfizerFactorSavingsCard.com and download your card today.

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OFFER TERMS: By using the Pfizer Factor Savings Card, you acknowledge that you currently meet the eligibility criteria and will comply with the terms and conditions described below:

The Card is not valid for prescriptions that are eligible to be reimbursed, in whole or in part, by Medicaid, Medicare, Tricare, or other federal or state health care programs (including any state prescription drug assistance programs) and the Government Health Insurance Plan available in Puerto Rico (formerly known as “La Reforma de Salud”). You may receive a total benefit of $12,000 per calendar year, or the amount of your co-pay over one year, whichever is less. This Card is not valid when the entire cost of your prescription drug is eligible to be reimbursed by your private insurance plans or other health or pharmacy benefit programs. You must deduct the value of this offer from any reimbursement request submitted to your insurance plan, either directly by you or on your behalf. The Card is not valid where prohibited by law. The Card cannot be combined with any other rebate/coupon, free trial, or similar offer for the specified prescription. The Card will be accepted only at participating factor suppliers. This Card is not health insurance. Offer good only in the United States and Puerto Rico. The Card is limited to 1 per person during this offering period and is not transferable. Pfizer reserves the right to rescind, revoke, or amend this offer without notice. Offer expires 12/31/18. No membership fees. Go to PfizerFactorSavingsCard.com and download your card today.